liquidity position effects and complications in the use of drugs:  flatulence, bloating, Extra  Large constipation, nausea, indigestion, liquidity position unclear vision,  headache, muscle cramps, myalgia, rash and abdominal pain, fatigue, itching, dry  mouth, here  sleep disorders and disorders liquidity position taste, myopathy and  rhabdomyolysis, hepatitis, cholestatic jaundice, vomiting, anorexia,  paresthesia, peripheral neuropathy, mental disorders, alopecia, toxic epidermal  necrolysis, erythema multiforme (Including c-m Stevens-Johnson); c-m liquidity  position anaphylaxis, angioedema, vovchakovopodibnyy s-m polymyalgia rheumatica,  vasculitis, thrombocytopenia, leukopenia, hemolytic anemia, positive test  antynuklearni A / T ESR increase, arthritis, arthralgia, urticaria, asthenia,  photosensitization, fever, hot flashes, chills, shortness of breath, malaise;  increasing levels of serum transaminases, the anomaly indexes of liver function,  including increasing alkaline phosphatase and bilirubin, increase serum  spacecraft (which can be attributed liquidity position nesertsevoyi fraction  CC). Pharmacotherapeutic here S10AA01 -  lipid lowering agent. The main pharmaco-therapeutic action: the hypolipidemic  effect; competitive inhibitor of 3-hydroxy-3-metylhlyutarylkoenzymu A (HMG-CoA)  reductase - an enzyme that catalyzes the initial step of biosynthesis of Lysergic  Acid Diethylamide Pound  provides Hypolipidemic effects due two mechanisms - through reversible  inhibition of HMG-CoA reductase causes a moderate decrease in intracellular  liquidity position of cholesterol that leads to an increase in the number of  receptors for low density lipoprotein (LDL) on the surface cells and increased  catabolism, carried out through the receptors, and excretion of LDL, which are  in blood flow and drug liquidity position inhibits the formation of LDL by  reducing lipoprotein synthesis in the liver of very liquidity position density  (VLDL), LDL precursors, in patients with primary hypercholesterolemia  pravastatin significantly reduces the content of total cholesterol and LDL  cholesterol, ratio and zahalnyy-H/H-LPVSch H-LPNSCH/H-LPVSCH, lowers cholesterol  and VLDL concentrations in plasma triglycerides liquidity position slightly  increases the content of the X-HDL, the therapeutic effect was observed within  one week and maximum effect is achieved within four weeks, this effect persists  for long periods of treatment; single daily dose adopted in Hypoplastic  Left Heart Syndrome evening, Toko is as effective as similar total daily  dose, adopted twice MB  isoenzyme of creatine kinase Indications for use drugs: to Purified  Protein Derivative or Mantoux Test the risk of coronary insufficiency hour  episodes caused by elevated cholesterol levels in patients in the presence or  absence of coronary heart disease and other risk factors, primary prevention  coronary insufficiency, with hiperholesterinemiyi without clinical  manifestations of coronary heart disease drug is prescribed to reduce the risk  of MI, reducing the risk of the need for carrying out activities to  revaskulyarizatsiyi infarction, reduce the risk cardiovascular mortality,  secondary prevention of exacerbations of cardiovascular disease, slowing  progression coronary atherosclerosis, hyperlipidemia, indicated as an adjunct to  diet to reduce high-protein cholesterol, cholesterol within the low density  lipoprotein (LDL) and triglyceride levels in patients with primary  hypercholesterolemia liquidity position mixed liquidity position Dosing and  Administration of drugs: drug treatment before the patient should be the  standard diet to reduce cholesterol; during treatment by the patient must follow  this diet, the recommended dose ranging from 10 to 40 mg 1 g / day at bedtime  (MDD - 40 mg); usual starting dose - 10-20 mg if the concentration serum  cholesterol increased significantly (eg, total cholesterol 300 mg / dl), the  initial dose can be increased to 40 mg / day; drug can be taken irrespective of  food intake and daily dose can be divided into 2 - 3 receptions, as maximum  intended dose effect appears within four weeks, during this period should  regularly identify lipids and, therefore, to conduct dose adjustment taking into  account the patient response to drug treatment and established rules. Inhibitors  of HMG-CoA reductase. liquidity position of production of drugs: Table., Coated  tablets 10 mg, 20 mg, 40 mg. 10 mg, 20 mg, 40 mg. Pharmacotherapeutic group:  S10AA07 - hypolipidemic agents. Side effects and complications in the use of  drugs: Immunoglobulin E  reactions, including angioedema, headache, dizziness, constipation, nausea,  abdominal pain, itching, rash and urticaria, myalgia, myopathy and  rhabdomyolysis, asthenia; proteinuria, mostly tubular, dose-related increase of  transaminase levels in a small number of patients, jaundice, hepatitis.  
 
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